JAM-2

5 atoms · 跨 1 天 · 首见 2026-06-23 · 最近 2026-06-23

三色: 🟦 fact 4 · 🟥 take 1 · stance ▲5/▼0/◆0

来源: X 5

时态: fresh:5

标签: 好思考:5 · 好数字:4

叙事 (narrative) (5)

• 2026-06-23 ⭐ · achieved drug-grade fully computationally designed multispecific antibodies against five peptide-MHCs
  The first drug-grade, fully computationally designed multispecific antibodies against five peptide-MHCs: Routine picomolar T-cell activation/cell-killing EC50s, >100-fold selectivity, and drug-like developability
  tags: 好思考·好数字 · → daily
• 2026-06-23 ⭐ · generated dual-variant KRAS G12 multispecifics with picomolar to single-digit-nanomolar potency
  The first fully generatively designed, drug-grade dual-variant KRAS G12 multispecifics: They recruit primary T-cells from human donors to kill G12V and G12C presenting cells at pM to single-digit-nM potency, completely sparing wild-type.
  tags: 好思考·好数字 · → daily
• 2026-06-23 ⭐ · achieved angstrom-level agreement between Cryo-EM and de novo designs
  Atomic accuracy, from sequence alone: Angstrom-level agreement between Cryo-EM and JAM-2 de novo designs, requiring only target sequences (not structure) as input.
  tags: 好数字·好思考 · → daily
• 2026-06-23 ⭐ · designed, built, and tested five programs in ~6 weeks end-to-end
  Unrivaled speed with an AI-native in-house wet lab: Designed, built, and tested five programs in one parallelized campaign, end-to-end in-house in ~6 weeks.
  tags: 好数字·好思考 · → daily
• 2026-06-23 · zero-shot drug design capabilities
  expand zero-shot drug design beyond binding to the design of multifunctional medicines, the intracellular proteome, and state-of-the-art atomic precision
  tags: 好思考 · → daily

时间轴 (近 20)

• 2026-06-23 · narrative · zero-shot drug design capabilities · → daily
• 2026-06-23 · narrative · achieved drug-grade fully computationally designed multispec · → daily
• 2026-06-23 · narrative · generated dual-variant KRAS G12 multispecifics with picomola · → daily
• 2026-06-23 · narrative · achieved angstrom-level agreement between Cryo-EM and de nov · → daily
• 2026-06-23 · narrative · designed, built, and tested five programs in ~6 weeks end-to · → daily

← 实体目录 · 系统日志